Ampoules
- 25% DEXTROSE INJECTION B.P.
(Dextrose 25% in Water)
Description and Composition
Glucose use depends on metabolic rate. It is stored in the liver and muscle as glycogen.
Water use depends on clinical state of patient, body temperature and renal function. Excreted through the skin, lungs, and kidneys.
Indications
Used as a source of energy particularly in total parenteral nutrition. Dosage and Administration The dose is dependent upon the age, weight, and clinical condition of the patient. However, for non-diabetics, the maximum infusion rate should be 4mg/kg/minute. At this rate the hepatic glucose production is minimized and peripheral glucose uptake maximized. Should be administered through central vein as it can be irritating to the peripheral veins causing phlebitis.
- Glucose use depends on metabolic rate. It is stored in the liver and muscle as glycogen.
- Water use depends on clinical state of patient, body temperature and renal function. Excreted through the skin, lungs, and kidneys.
- Since the tonicity is low, avoid using in head injury patients.
- Use sterile technique in venipuncture and equipment assembly.
- Do not use solution if outdated, cloudy or the seal is not intact.
- Monitor E.C.G. continuously.
- Monitor blood pressure, pulse rate and respiratory rate frequently.
- Monitoring of blood glucose is advisable.
Osmolarity and Tonicity
- Hypotonic solution as it does not contain any cations.
- Hyper-osmolar solution (1389 mOsm/L)
Caloric Value
935 kCal/Liter
Pharmaceutical Precautions
- Store at room temperature. Protect from sunlight.
- Do not use if bottle is leaking, solution is cloudy or contains foreign matter.
- Discard unused portion.
- Keep all medicines out of the reach of children.
1000ml in Plabottle.
Pharmacological Effects
25% DEXTROSE INJECTION B.P.
(Dextrose 25% in Water)
Description and Composition
Glucose use depends on metabolic rate. It is stored in the liver and muscle as glycogen.
Water use depends on clinical state of patient, body temperature and renal function. Excreted through the skin, lungs, and kidneys.
Indications
Used as a source of energy particularly in total parenteral nutrition. Dosage and Administration The dose is dependent upon the age, weight, and clinical condition of the patient. However, for non-diabetics, the maximum infusion rate should be 4mg/kg/minute. At this rate the hepatic glucose production is minimized and peripheral glucose uptake maximized. Should be administered through central vein as it can be irritating to the peripheral veins causing phlebitis.
Pharmacological Effects
Pharmacological Effects
​Provides calories for some metabolic needs. Each 100mL provides 25 grams of Dextrose and each gram of Dextrose Monohydrate provides 3.4kCal. Depending on the presence of insulin, glucose enters cells and is broken down to pyruvate. With adequate oxygen,it enters the Kreb's cycle in the mitochondria and is converted into energy (A.T.P.), CO2 and H2O. The brain does not require insulin for glucose metabolism.
Supplies body water for hydration.
Spares body protein by providing carbohydrate for metabolism.
Osmolarity of D25W is 1389 mOsm/L. The fluid is isotonic when in the container. After administration, the dextrose is quickly metabolized in the body, leaving only water - a hypotonic fluid.
The pH range is 3.5 - 6.5.
Capable of producing diuresis depending on clinical state of the patient.
Supplies body water for hydration.
Spares body protein by providing carbohydrate for metabolism.
Osmolarity of D25W is 1389 mOsm/L. The fluid is isotonic when in the container. After administration, the dextrose is quickly metabolized in the body, leaving only water - a hypotonic fluid.
The pH range is 3.5 - 6.5.
Capable of producing diuresis depending on clinical state of the patient.