Clinical Nutrition

- AMINOVEL 600

Description and Composition

Each 1000 mL contains: 

D-Sorbitol:    100.0 g
L-Alanine:    6.0 g
L-Arginine:    6.2 g
L-Histidine:    1.0 g
L-Isoleucine:    3.2 g
L-Leucine:    2.4 g
L-Lysine:    2.0 g
L_Methionine:    3.0 g
L-Phenylalanine:    4.0 g
L-Proline:    2.0 g
L-Threonine:    2.0 g
L-Tryptophan:    1.0 g
L-Valine:    3.2 g
Glycine (Aminoacetic acid):    14.0 g
Ascorbic acid:    400.0 mg
Inositol:    500.0 mg
Nicotinamide:    60.0 mg
Pyridoxine HCl:    40.0 mg
Riboflavin Sodium Phosphate:    2.5 mg
Sodium:    35 mEq
Potassium:    25 mEq
Magnesium:    5 mEq
Acetate:    35 mEq
Malate:    22 mEq
Chloride:    38 mEq
Water for Injection:    q.s.
Free AA:    5% (w/v)
Essential AA (E):    20.8 (w/v)
Non-Essential AA (N):    29.2 (w/v)
E/N:    0.7
Total Nitrogen:    8.0 g/L
Osmolarity:    1320 mOsm/L

Indications
Recommended for provision of amino acids and energy in patients who require intravenous nutrition. Such conditions include surgery, infections, trauma, burns, prolonged disorders of the gastrointestinal tract, protein deficiency, preparation of patients for surgery, chemotherapy or radiation therapy, prolonged coma or refusal to eat. 
Dosage and Administration

Generally proteins are provided in a daily dose of 0.8-1.0 g/kg for maintenance and 1.2-2.0 g/kg in catabolic states. The usual adult dosage of Aminovel 600 is 500 ml via intravenous infusion over 4-6 hours (20-30 drops/min). The dosage may be adjusted according to the patient’s condition, body weight and age. The infusion rate should be slowed in elderly and severely ill patients. 

Contraindications

Hypersensitivity to any ingredient of the preparation. Hereditary fructose intolerance, hepatic coma, azotemia, congestive cardiac failure, severe acidosis and disturbances of amino acid metabolism. 

Precautions

Aminovel 600 should be administered with care in patients with severe hepatic and renal disorders, diabetes mellitus and in elderly. Care is required in patients with reduced urine output due to high potassium content. It should be used in pregnant patients after careful assessment and only if the therapeutic benefits outweigh any potential risks associated with the treatment. 

Adverse Events

Hypersensitivity, chest discomfort and palpitations may occur. Occasionally nausea, vomiting and phlebitis may occur. 

Packaging

500 mL graduated glass bottles with rubber cap, packed in corrugated unit boxes with air filter. Packs of 12 bottles.
AMINOVEL 600
Description and Composition

Each 1000 mL contains: 

D-Sorbitol:    100.0 g
L-Alanine:    6.0 g
L-Arginine:    6.2 g
L-Histidine:    1.0 g
L-Isoleucine:    3.2 g
L-Leucine:    2.4 g
L-Lysine:    2.0 g
L_Methionine:    3.0 g
L-Phenylalanine:    4.0 g
L-Proline:    2.0 g
L-Threonine:    2.0 g
L-Tryptophan:    1.0 g
L-Valine:    3.2 g
Glycine (Aminoacetic acid):    14.0 g
Ascorbic acid:    400.0 mg
Inositol:    500.0 mg
Nicotinamide:    60.0 mg
Pyridoxine HCl:    40.0 mg
Riboflavin Sodium Phosphate:    2.5 mg
Sodium:    35 mEq
Potassium:    25 mEq
Magnesium:    5 mEq
Acetate:    35 mEq
Malate:    22 mEq
Chloride:    38 mEq
Water for Injection:    q.s.
Free AA:    5% (w/v)
Essential AA (E):    20.8 (w/v)
Non-Essential AA (N):    29.2 (w/v)
E/N:    0.7
Total Nitrogen:    8.0 g/L
Osmolarity:    1320 mOsm/L

Indications
Recommended for provision of amino acids and energy in patients who require intravenous nutrition. Such conditions include surgery, infections, trauma, burns, prolonged disorders of the gastrointestinal tract, protein deficiency, preparation of patients for surgery, chemotherapy or radiation therapy, prolonged coma or refusal to eat.