Clinical Nutrition - AMINOVEL 600
Description and Composition
Each 1000 mL of Aminovel 600 contains:
| Nutrient | Amount |
|---|---|
| D-Sorbitol | 100.0 g |
| L-Alanine | 6.0 g |
| L-Arginine | 6.2 g |
| L-Histidine | 1.0 g |
| L-Isoleucine | 3.2 g |
| L-Leucine | 2.4 g |
| L-Lysine | 2.0 g |
| L-Methionine | 3.0 g |
| L-Phenylalanine | 4.0 g |
| L-Proline | 2.0 g |
| L-Threonine | 2.0 g |
| L-Tryptophan | 1.0 g |
| L-Valine | 3.2 g |
| Glycine (Aminoacetic acid) | 14.0 g |
| Ascorbic acid | 400.0 mg |
| Inositol | 500.0 mg |
| Nicotinamide | 60.0 mg |
| Pyridoxine HCl | 40.0 mg |
| Riboflavin Sodium Phosphate | 2.5 mg |
| Sodium | 35 mEq |
| Potassium | 25 mEq |
| Magnesium | 5 mEq |
| Acetate | 35 mEq |
| Malate | 22 mEq |
| Chloride | 38 mEq |
| Water for Injection | q.s. |
| Free AA | 5% (w/v) |
| Essential AA (E) | 21.8% (w/v) |
| Non-Essential AA (N) | 28.2% (w/v) |
| E/N | 0.7 |
| Total Nitrogen | 8.0 g/L |
| Osmolarity | 1320 mOsm/L |
Indications
Recommended for provision of amino acids and energy in patients who require intravenous nutrition. Conditions include surgery, infections, trauma, burns, prolonged gastrointestinal disorders, protein deficiency, preparation for surgery, chemotherapy or radiation therapy, prolonged coma, or refusal to eat.
Dosage and Administration
Generally, proteins are provided in a daily dose of 0.8-1.0 g/kg for maintenance and 1.2-2.0 g/kg in catabolic states. The usual adult dosage of Aminovel 600 is 500 mL via intravenous infusion over 4-6 hours (20-30 drops/min). The dosage may be adjusted based on the patient’s condition, body weight, and age. The infusion rate should be slowed in elderly and severely ill patients.
Contraindications
Hypersensitivity to any ingredient of the preparation. Hereditary fructose intolerance, hepatic coma, azotemia, congestive cardiac failure, severe acidosis, and disturbances of amino acid metabolism.
Precautions
Aminovel 600 should be administered with care in patients with severe hepatic and renal disorders, diabetes mellitus, and in the elderly. Care is required in patients with reduced urine output due to high potassium content. It should be used in pregnant patients only after careful assessment if the therapeutic benefits outweigh potential risks.
Adverse Events
Hypersensitivity, chest discomfort, and palpitations may occur. Occasionally, nausea, vomiting, and phlebitis may occur.
Packaging
Aminovel is available in a 500 mL plastic bottle securely packaged in a high-quality aluminum foil bag. An oxygen absorber is included in each bottle to eliminate the chances of amino acid oxidation.